|mutations e484k l452r et k417n||0.82||0.6||9911||26|
|mutations e484k et l452r||1.7||0.4||8758||93|
|mutations e484k e484q et l452r||0.83||0.8||7903||64|
|presence des mutations k417n et l452r||1.46||0.3||619||57|
|présence des mutations k417n et l452r||1.2||0.1||5598||8|
|les mutations e484k e484q et l452r||1.18||0.3||5839||2|
|mutation k417n et l452r||0.86||0.9||3181||96|
|l452r et de la mutation k417n||0.17||0.7||3763||29|
|mutation l452r et mutation k417n||1.15||0.6||5263||67|
|détection des mutations l452r et k417n||0.69||0.1||4788||1|
|présence de la mutation k417n et l452r||1.15||0.1||157||22|
|mutation l452r et de la mutation k417n||1.72||0.2||2528||21|
|mutations e484k e484q l452r||1.14||0.8||6573||35|
|porteur de la mutation l452r et k417n||0.32||0.9||821||15|
|mutation k417n et l452r quel variant||1.64||0.4||9598||79|
Five mutations N501Y, E484K/Q, K417N/T, L452R and T478K, located in the spike protein RBD, have had a greater biological impact because they were associated with new attributes developed by the virus, which served as a basis for characterizing the variants of concern (VOC) of SARS-Cov-2 that emerged in the pandemic context.What is k417n mutation?
Characterized by the replacement of a lysine (K) residue with a arparagine (N) residue (K417N), this mutation, although it does not contribute to binding toACE2 receptor (since it is outside the RBM), occurs in an epitope for neutralizing antibodies ( Tada et al., 2021a ).What is the e484k mutation?
The E484K mutation comprises the substitution of a residue with a glutamate (E) with a lysine (K) at position 484 (E484K) in the RBD. The amino acid at that position serves as a contact point for ACE2 ( Lan et al., 2020 ).What is the significance of the l452r mutation?
L452R is a relevant mutation in this strain that enhances ACE2 receptor binding ability and can reduce vaccine-stimulated antibodies from attaching to this altered spike protein. L452R, some studies show, could even make the coronavirus resistant to T cells, that are class of cells necessary to target and destroy virus-infected cells.