| Keyword | CPC | PCC | Volume | Score |
|---|---|---|---|---|
| mutations e484k l452r et k417n | 0.82 | 0.6 | 9911 | 26 |
| mutations e484k et l452r | 1.7 | 0.4 | 8758 | 93 |
| mutations e484k e484q et l452r | 0.83 | 0.8 | 7903 | 64 |
| presence des mutations k417n et l452r | 1.46 | 0.3 | 619 | 57 |
| présence des mutations k417n et l452r | 1.2 | 0.1 | 5598 | 8 |
| les mutations e484k e484q et l452r | 1.18 | 0.3 | 5839 | 2 |
| mutation k417n et l452r | 0.86 | 0.9 | 3181 | 96 |
| l452r et de la mutation k417n | 0.17 | 0.7 | 3763 | 29 |
| mutation l452r et mutation k417n | 1.15 | 0.6 | 5263 | 67 |
| détection des mutations l452r et k417n | 0.69 | 0.1 | 4788 | 1 |
| présence de la mutation k417n et l452r | 1.15 | 0.1 | 157 | 22 |
| mutation l452r et de la mutation k417n | 1.72 | 0.2 | 2528 | 21 |
| mutations e484k e484q l452r | 1.14 | 0.8 | 6573 | 35 |
| porteur de la mutation l452r et k417n | 0.32 | 0.9 | 821 | 15 |
| mutation k417n et l452r quel variant | 1.64 | 0.4 | 9598 | 79 |
Five mutations N501Y, E484K/Q, K417N/T, L452R and T478K, located in the spike protein RBD, have had a greater biological impact because they were associated with new attributes developed by the virus, which served as a basis for characterizing the variants of concern (VOC) of SARS-Cov-2 that emerged in the pandemic context.
What is k417n mutation?Characterized by the replacement of a lysine (K) residue with a arparagine (N) residue (K417N), this mutation, although it does not contribute to binding toACE2 receptor (since it is outside the RBM), occurs in an epitope for neutralizing antibodies ( Tada et al., 2021a ).
What is the e484k mutation?The E484K mutation comprises the substitution of a residue with a glutamate (E) with a lysine (K) at position 484 (E484K) in the RBD. The amino acid at that position serves as a contact point for ACE2 ( Lan et al., 2020 ).
What is the significance of the l452r mutation?L452R is a relevant mutation in this strain that enhances ACE2 receptor binding ability and can reduce vaccine-stimulated antibodies from attaching to this altered spike protein. L452R, some studies show, could even make the coronavirus resistant to T cells, that are class of cells necessary to target and destroy virus-infected cells.
