| Keyword | CPC | PCC | Volume | Score | Length of keyword |
|---|---|---|---|---|---|
| mutation e484k l452r k417n | 1.53 | 0.1 | 3663 | 26 | 26 |
| mutation | 1.77 | 0.8 | 1037 | 29 | 8 |
| e484k | 0.68 | 1 | 2923 | 73 | 5 |
| l452r | 0.67 | 0.4 | 489 | 29 | 5 |
| k417n | 1.94 | 0.6 | 6811 | 63 | 5 |
| Keyword | CPC | PCC | Volume | Score |
|---|---|---|---|---|
| mutation e484k l452r k417n | 1.8 | 0.1 | 2999 | 22 |
| présence des mutations e484k k417n et l452r | 1.77 | 0.8 | 9558 | 62 |
| mutation l452r et mutation k417n | 0.63 | 0.2 | 3248 | 34 |
| mutation l452r et de la mutation k417n | 1.79 | 0.4 | 3741 | 9 |
| mutation e484k e484q l452r | 1.03 | 0.4 | 5692 | 16 |
| mutation e484k et k417n | 1.17 | 0.8 | 51 | 29 |
| mutation k417n et l452r | 0.8 | 0.5 | 5850 | 52 |
| l452r et de la mutation k417n | 1.08 | 0.8 | 7414 | 39 |
| absence des mutations e484k l452r et k417n | 1.87 | 0.3 | 9417 | 65 |
| mutations e484k e484q l452r | 1.68 | 0.4 | 2227 | 11 |
| mutations k417n et l452r | 1.64 | 0.7 | 9561 | 31 |
| présence de la mutation k417n et l452r | 1.64 | 0.6 | 5508 | 48 |
| mutations e484k et l452r | 0.11 | 0.5 | 563 | 31 |
| porteur de la mutation l452r et k417n | 0.49 | 0.3 | 4868 | 68 |
| mutation k417n et l452r quel variant | 0.48 | 0.3 | 4655 | 6 |
| mutations e484k e484q et l452r | 1.06 | 0.8 | 1552 | 11 |
| presence des mutations k417n et l452r | 0.76 | 0.1 | 5425 | 47 |
| présence des mutations k417n et l452r | 1.27 | 0.6 | 7662 | 36 |
| les mutations e484k e484q et l452r | 0.08 | 0.7 | 2523 | 42 |
Five mutations N501Y, E484K/Q, K417N/T, L452R and T478K, located in the spike protein RBD, have had a greater biological impact because they were associated with new attributes developed by the virus, which served as a basis for characterizing the variants of concern (VOC) of SARS-Cov-2 that emerged in the pandemic context.
What is the e484k mutation?The E484K mutation comprises the substitution of a residue with a glutamate (E) with a lysine (K) at position 484 (E484K) in the RBD. The amino acid at that position serves as a contact point for ACE2 ( Lan et al., 2020 ).
What is the significance of the l452r mutation?L452R is a relevant mutation in this strain that enhances ACE2 receptor binding ability and can reduce vaccine-stimulated antibodies from attaching to this altered spike protein. L452R, some studies show, could even make the coronavirus resistant to T cells, that are class of cells necessary to target and destroy virus-infected cells.
