Keyword Analysis & Research: mutation e484k l452r k417n


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What is the significance of mutations n501y e484k/q k417n/t and l452r?

Five mutations N501Y, E484K/Q, K417N/T, L452R and T478K, located in the spike protein RBD, have had a greater biological impact because they were associated with new attributes developed by the virus, which served as a basis for characterizing the variants of concern (VOC) of SARS-Cov-2 that emerged in the pandemic context.

What is the e484k mutation?

The E484K mutation comprises the substitution of a residue with a glutamate (E) with a lysine (K) at position 484 (E484K) in the RBD. The amino acid at that position serves as a contact point for ACE2 ( Lan et al., 2020 ).

What is the significance of the l452r mutation?

L452R is a relevant mutation in this strain that enhances ACE2 receptor binding ability and can reduce vaccine-stimulated antibodies from attaching to this altered spike protein. L452R, some studies show, could even make the coronavirus resistant to T cells, that are class of cells necessary to target and destroy virus-infected cells.


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