|mutation e484k l452r k417n||1.8||0.1||2999||22|
|présence des mutations e484k k417n et l452r||1.77||0.8||9558||62|
|mutation l452r et mutation k417n||0.63||0.2||3248||34|
|mutation l452r et de la mutation k417n||1.79||0.4||3741||9|
|mutation e484k e484q l452r||1.03||0.4||5692||16|
|mutation e484k et k417n||1.17||0.8||51||29|
|mutation k417n et l452r||0.8||0.5||5850||52|
|l452r et de la mutation k417n||1.08||0.8||7414||39|
|absence des mutations e484k l452r et k417n||1.87||0.3||9417||65|
|mutations e484k e484q l452r||1.68||0.4||2227||11|
|mutations k417n et l452r||1.64||0.7||9561||31|
|présence de la mutation k417n et l452r||1.64||0.6||5508||48|
|mutations e484k et l452r||0.11||0.5||563||31|
|porteur de la mutation l452r et k417n||0.49||0.3||4868||68|
|mutation k417n et l452r quel variant||0.48||0.3||4655||6|
|mutations e484k e484q et l452r||1.06||0.8||1552||11|
|presence des mutations k417n et l452r||0.76||0.1||5425||47|
|présence des mutations k417n et l452r||1.27||0.6||7662||36|
|les mutations e484k e484q et l452r||0.08||0.7||2523||42|
Five mutations N501Y, E484K/Q, K417N/T, L452R and T478K, located in the spike protein RBD, have had a greater biological impact because they were associated with new attributes developed by the virus, which served as a basis for characterizing the variants of concern (VOC) of SARS-Cov-2 that emerged in the pandemic context.What is the e484k mutation?
The E484K mutation comprises the substitution of a residue with a glutamate (E) with a lysine (K) at position 484 (E484K) in the RBD. The amino acid at that position serves as a contact point for ACE2 ( Lan et al., 2020 ).What is the significance of the l452r mutation?
L452R is a relevant mutation in this strain that enhances ACE2 receptor binding ability and can reduce vaccine-stimulated antibodies from attaching to this altered spike protein. L452R, some studies show, could even make the coronavirus resistant to T cells, that are class of cells necessary to target and destroy virus-infected cells.