Keyword Analysis & Research: alpha 1 antitrypsin deficiency genotypes

bing.com

https://www.bing.com/aclk?ld=e8Hy5xBo7s2aefY0h3FgDE3DVUCUxxOQ6FHRg3Yw6dx3Ijj-mjylZZJ1CoETzP8lI3FtS4MJQoaGXw-UxKPqlZCOhgqWDr17VfSiI8sjrbkX9hbWbo7h6SWG12OpCI-tGBdTnnTnQzpo0RHnvtrr_Y6ytGmAieXhGhk9lj_dWOZetMlbeW&u=aHR0cHMlM2ElMmYlMmZ3d3cuYWxwaGFpZC5jb20lMmZlbiUyZmhjcCUyZm9yZGVyLWZyZWUtYWxwaGFpZC1zY3JlZW5pbmctdGVzdC1raXRzJTNmdXRtX2lkJTNkNDM3MzAwMTAzJTI2bXNjbGtpZCUzZDdlOGQzM2Y0OTAyYzEyMDZjZTgzNTVkOTgzZTdiOWU2JTI2dXRtX3NvdXJjZSUzZGJpbmclMjZ1dG1fbWVkaXVtJTNkY3BjJTI2dXRtX2NhbXBhaWduJTNkMjAyMiUyNTIwQUFURCUyNTIwVGVzdGluZyUyNTIwLSUyNTIwQ09OViUyNnV0bV90ZXJtJTNkYWxwaGElMjUyMGFudGl0cnlwc2luJTI1MjBkZWZpY2llbmN5JTI1MjBzY3JlZW4lMjZ1dG1fY29udGVudCUzZEFBVEQlMjUyMHNjcmVlbmluZw&rlid=7e8d33f4902c1206ce8355d983e7b9e6

DA: 24 PA: 40 MOZ Rank: 99

nih.gov

https://www.ncbi.nlm.nih.gov/books/NBK442030/

WebFeb 7, 2023 · USA.gov. Alpha-1 antitrypsin (AAT) deficiency is a clinically under-recognized genetic disorder that causes the defective production of alpha-1 antitrypsin protein. AAT protein protects the body from the neutrophil elastase enzyme which is released from white blood cells to fight infection.

DA: 30 PA: 49 MOZ Rank: 66

nejm.org

https://www.nejm.org/doi/full/10.1056/NEJMra1910234

WebApr 8, 2020 · Alpha1-antitrypsin (AAT) deficiency is one of the most common genetic diseases. Most persons carry two copies of the wild-type M allele of SERPINA1, which encodes AAT, and have normal...

DA: 63 PA: 93 MOZ Rank: 80

alphanet.org

https://www.alphanet.org/what-is-alpha-1/gene-types/

WebAlpha-1 antitrypsin deficiency is a genetic condition. The Alpha-1 gene has over 100 variants. Some of these variants stop your body from producing enough normal Alpha-1. These gene variations are known as “alleles”. The normal variant of …

DA: 37 PA: 98 MOZ Rank: 75

wikipedia.org

https://en.wikipedia.org/wiki/Alpha-1_antitrypsin_deficiency

WebGenetics. Serpin peptidase inhibitor, clade A, member 1 ( SERPINA1) is the gene that encodes the protein alpha-1 antitrypsin. SERPINA1 has been localized to chromosome 14q32. Over 75 mutations of the SERPINA1 gene have been identified, many with clinically significant effects. [11]

DA: 49 PA: 39 MOZ Rank: 74

nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886062/

WebOct 28, 2020 · The alpha-1 antitrypsin (AAT) protein is encoded by the SERPINA1 gene on chromosome 14, and its main function is to inactivate neutrophil elastase (NE) upon insult to the lungs, such as smoking.

DA: 99 PA: 2 MOZ Rank: 44

atsjournals.org

https://www.atsjournals.org/doi/10.1513/AnnalsATS.201507-436KV

WebJul 15, 2015 · Alpha-1 antitrypsin deficiency (AATD) is the best recognized genetic predisposing factor to the development of chronic obstructive airway disease (COPD) both in smokers and never-smokers. It is classically considered to be associated with early-onset and rapidly progressive lower zone panlobular emphysema ( 1 ).

DA: 82 PA: 54 MOZ Rank: 23

nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983484/

WebAlpha-1 antitrypsin deficiency occurs in individuals with deleterious genetic mutations on both chromosomes (maternal and paternal) in SERPINA1, the gene encoding the alpha-1 antitrypsin protein. There has been substantial progress in understanding the genetic variation that underlies the heterogeneous penetrance of lung disease in alpha-1 ...

DA: 16 PA: 21 MOZ Rank: 18

genome.gov

https://www.genome.gov/Genetic-Disorders/Alpha-1-Antitrypsin-Deficiency

WebJan 4, 2012 · Alpha-1 antitrypsin deficiency (AATD) is an inherited condition that causes low levels of, or no, alpha-1 antitrypsin (AAT) in the blood. AATD occurs in approximately 1 in 2,500 individuals. This condition is found in all ethnic groups; however, it occurs most often in whites of European ancestry.

DA: 68 PA: 33 MOZ Rank: 30

uptodate.com

https://www.uptodate.com/contents/clinical-manifestations-diagnosis-and-natural-history-of-alpha-1-antitrypsin-deficiency

WebNov 17, 2023 · Alpha-1 antitrypsin (AAT) deficiency is a clinically under-recognized inherited disorder affecting the lungs, liver, and rarely, skin. In the lungs, AAT deficiency causes chronic obstructive pulmonary disease (ie, emphysema and bronchiectasis).

DA: 45 PA: 58 MOZ Rank: 78

medlineplus.gov

https://medlineplus.gov/genetics/condition/alpha-1-antitrypsin-deficiency/

WebDescription. Alpha-1 antitrypsin deficiency is an inherited disorder that may cause lung disease and liver disease. The signs and symptoms of the condition and the age at which they appear vary among individuals. People with alpha-1 antitrypsin deficiency usually develop the first signs and symptoms of lung disease between ages 25 and 50.

DA: 31 PA: 8 MOZ Rank: 69

bing.com

https://www.bing.com/aclk?ld=e8Hy5xBo7s2aefY0h3FgDE3DVUCUxxOQ6FHRg3Yw6dx3Ijj-mjylZZJ1CoETzP8lI3FtS4MJQoaGXw-UxKPqlZCOhgqWDr17VfSiI8sjrbkX9hbWbo7h6SWG12OpCI-tGBdTnnTnQzpo0RHnvtrr_Y6ytGmAieXhGhk9lj_dWOZetMlbeW&u=aHR0cHMlM2ElMmYlMmZ3d3cuYWxwaGFpZC5jb20lMmZlbiUyZmhjcCUyZm9yZGVyLWZyZWUtYWxwaGFpZC1zY3JlZW5pbmctdGVzdC1raXRzJTNmdXRtX2lkJTNkNDM3MzAwMTAzJTI2bXNjbGtpZCUzZDdlOGQzM2Y0OTAyYzEyMDZjZTgzNTVkOTgzZTdiOWU2JTI2dXRtX3NvdXJjZSUzZGJpbmclMjZ1dG1fbWVkaXVtJTNkY3BjJTI2dXRtX2NhbXBhaWduJTNkMjAyMiUyNTIwQUFURCUyNTIwVGVzdGluZyUyNTIwLSUyNTIwQ09OViUyNnV0bV90ZXJtJTNkYWxwaGElMjUyMGFudGl0cnlwc2luJTI1MjBkZWZpY2llbmN5JTI1MjBzY3JlZW4lMjZ1dG1fY29udGVudCUzZEFBVEQlMjUyMHNjcmVlbmluZw&rlid=7e8d33f4902c1206ce8355d983e7b9e6

DA: 73 PA: 33 MOZ Rank: 82