vmat2 | Vesicular monoamine transporter 2

Keyword	CPC	PCC	Volume	Score	Length of keyword
vmat2	0.66	0.2	6956	89	5

Keyword	CPC	PCC	Volume	Score
vmat2	0.66	0.5	1701	31
vmat2 inhibitor	0.9	0.4	6811	77
vmat2 gene	1.94	0.3	6075	73
vmat2 inhibitor drugs	1.81	0.8	2267	66
vmat2 dopamine neuron	1.34	0.8	3695	96
vmat2 structure	0.81	0.1	7248	87
vmat2 function	0.06	0.1	1040	68
vmat2 nature	0.09	1	3865	21
vmat2 god gene	0.95	0.5	7779	5
vmat2 inhibitor examples	0.3	0.9	5775	56
vmat2 inhibitors list	1.15	0.9	6124	74

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Vesicular monoamine transporter 2 - Wikipedia
wikipedia.org

https://en.wikipedia.org/wiki/Vesicular_monoamine_transporter_2

WEBThe solute carrier family 18 member 2 (SLC18A2) also known as vesicular monoamine transporter 2 (VMAT2) is a protein that in humans is encoded by the SLC18A2 gene. SLC18A2 is an integral membrane protein that transports monoamines —particularly neurotransmitters such as dopamine , norepinephrine , serotonin , and histamine …

DA: 35 PA: 70 MOZ Rank: 88

Transport and inhibition mechanisms of human VMAT2 | Nature
nature.com

https://www.nature.com/articles/s41586-023-06926-4

WEBNov 1, 2023 · Vesicular monoamine transporter 2 (VMAT2) accumulates monoamines in presynaptic vesicles for storage and exocytotic release, and has a vital role in monoaminergic neurotransmission 1, 2,...

DA: 41 PA: 63 MOZ Rank: 41

Vesicular Monoamine Transporter 2 (VMAT2) Inhibitors
nih.gov

https://www.ncbi.nlm.nih.gov/books/NBK548187/

WEBApr 2, 2019 · USA.gov. The vesicular monoamine transporter type 2 (VMAT2) inhibitors are agents that cause a depletion of neuroactive peptides such as dopamine in nerve terminals and are used to treat chorea due to neurodegenerative diseases (such as Huntington chorea) or dyskinesias due to neuroleptic medications (tardive dyskinesia).

DA: 13 PA: 84 MOZ Rank: 91

VMAT2: a dynamic regulator of brain monoaminergic neuronal …
nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183197/

WEBThe presence of VMAT2 in noradrenergic, serotoninergic, histaminergic, and potentially trace aminergic neurons invites consideration of a wider role for aminergic neurotransmission in AMPH and COC abuse and addiction. Keywords: VMAT2, amphetamine, cocaine, addiction, monoamines, vesicular transporter. Go to:

DA: 51 PA: 15 MOZ Rank: 19

Mechanisms of neurotransmitter transport and drug inhibition in human VMAT2
nature.com

https://www.nature.com/articles/s41586-023-06727-9

WEBNov 1, 2023 · Tetrabenazine binds VMAT2 in a lumen-facing conformation, locking the luminal gating lid in an occluded state to arrest the transport cycle. By contrast, reserpine binds in a cytoplasm-facing...

DA: 93 PA: 67 MOZ Rank: 97

Transport and inhibition mechanism for VMAT2-mediated …
nature.com

https://www.nature.com/articles/s41422-023-00906-z

WEBJan 2, 2024 · VMAT2 inhibitors reserpine and tetrabenazine are used to treat hypertension, movement disorders associated with Huntington’s Disease and Tardive Dyskinesia. Despite its physiological and...

DA: 44 PA: 92 MOZ Rank: 12

The vesicular monoamine transporter 2: an underexplored …
nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028832/

WEBCurrent therapeutics targeting VMAT2. Despite the recognized importance of the vesicle in dopaminergic disease, few FDA approved drugs directly and specifically target the vesicle. Two VMAT2 inhibitors, reserpine and tetrabenazine (TBZ), have demonstrated efficacy in the treatment of disease.

DA: 92 PA: 67 MOZ Rank: 84

VMAT2: a dynamic regulator of brain monoaminergic neuronal …
nih.gov

https://pubmed.ncbi.nlm.nih.gov/21272013/

WEBJan 11, 2020 · The presence of VMAT2 in noradrenergic, serotoninergic, histaminergic, and potentially trace aminergic neurons invites consideration of a wider role for aminergic neurotransmission in AMPH and COC abuse and addiction. © 2011 New York Academy of Sciences. Publication types. Review. MeSH terms. Amphetamine / pharmacology. Animals.

DA: 96 PA: 99 MOZ Rank: 91

Vesicular Monoamine Transporter 2 (VMAT2) | SpringerLink
springer.com

https://link.springer.com/referenceworkentry/10.1007/978-3-319-28845-1_5320-1

WEBAug 7, 2021 · VMAT2 is a monoamine transporter responsible for the storage of cytosolic monoamines into vesicles using an ATPase-dependent H + gradient. Features. Discovered in 1992 from rat brain and encoded on chromosome 10q25.3, VMAT2 is a monoamine transporter located on the membrane of both dense core large vesicles and small …

DA: 96 PA: 72 MOZ Rank: 23

Vesicular Monoamine Transporter 2 - an overview - ScienceDirect
sciencedirect.com

https://www.sciencedirect.com/topics/neuroscience/vesicular-monoamine-transporter-2

WEBVMAT2 is critical as a functional component of monoaminergic neurotransmission. Within presynaptic terminals of monoaminergic neurons, VMAT2 translocates monoamines from the cytosol across the vesicle membrane into the vesicle lumen following neurotransmitter biosynthesis and/or clearance from the extracellular space.

DA: 87 PA: 33 MOZ Rank: 69