**Accumulation: What It Means and How to Calculate It**
https://www.certara.com/knowledge-base/accumulation-what-it-means-and-how-to-calculate-it/

Nov 20, 2012 · If the elimination rate constant cannot be calculated (e.g. t 1/2 is > 6 hours, and τ is 24 hrs), one could calculate the accumulation ratio using method 2 (e.g. AUC or C max), and then input that AR value into the equation for method 1, and solve for k. As mentioned previously, using method 1, the AR can be calculated for a variety of dosing ...

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