Keyword Analysis & Research: pitavastatin lcms


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What is the plasma Cmax of pitavastatin?

The pharmacokinetics results showed that plasma Cmax values of pitavastatin at three single dosage levels were 27.8 ± 9.11, 51.5 ± 15.0 and 108 ± 45.5 ng/ml, respectively. The absorption of pitavastatin was rapid, with t1/2 occurring 0.65 ± 0.17, 0.81 ± 0.34 and 0.88 ± 0.18 h, respectively.

Is pitavastatin a more selective oatp1b inhibitor than rosuvastatin?

The results indicate that pitavastatin is a more sensitive and selective and thus preferred clinical OATP1B probe substrate than rosuvastatin, and that a single IV dose of rifampicin is a more selective OATP1B inhibitor than a PO dose.

Is pitavastatin a substrates of NTCP?

Notably, pitavastatin and rosuvastatin are reportedly substrates of NTCP, MDR1 Pgp and MRP2 in human hepatocytes, as well as in OATP1B1 + Pgp and OATP1B1 + MRP2 double-transfected cell monolayers 3,26,27.

What is the AUC of pitavastatin?

Pitavastatin AUC0–4 h(ng h ml−1) 21.0 ± 7.1 145.7 ± 44.1 118.0 ± 53.0 7.08 (6.47, 7.74) 5.21 (4.16, 6.52) 0.74 (0.58, 0.94) AUC0–∞(ng h ml−1)


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