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Why is it called a nonsense mutation?

Why is it called a nonsense mutation? Stop codons are also called nonsense codons because they do not code for an amino acid and instead signal the end of protein synthesis. Thus, nonsense mutations occur when a premature nonsense or stop codon is introduced in the DNA sequence.

What does nonsense mutation mean?

Nonsense Mutation Definition 1. A point mutation occurring within the protein-coding region of a gene, and which codes for a stop that can truncate the protein. (NCI Thesaurus) Definition 2. A mutation that alters the genetic code in a way that causes the premature termination of a protein.

How does a nonsense mutation affect the body?

Nonsense mutation. A nonsense mutation is also a change in one DNA base pair. Instead of substituting one amino acid for another, however, the altered DNA sequence prematurely signals the cell to stop building a protein. This type of mutation results in a shortened protein that may function improperly or not at all.


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