mutational load | Genetic load

Keyword	CPC	PCC	Volume	Score	Length of keyword
mutational load	1.47	0.9	4832	89	15
mutational	1.42	1	8422	68	10
load	0.09	0.5	7056	36	4

Keyword	CPC	PCC	Volume	Score
mutational load	1.7	0.7	8534	38
mutational load definition	1.88	0.6	5710	40
mutational load theory	0.06	0.9	5795	14
high mutational load	0.93	0.7	5652	60
singularity mutational load	0.31	1	5347	71
what is mutational load	1.59	0.9	4124	31
increasing mutational load	0.97	0.2	4631	25
tumor mutational load	0.72	0.4	5381	35
somatic mutational load	0.84	0.5	6642	62
high mutational load in developed countries	0.09	1	8455	82

Search Results related to mutational load on Search Engine

Genetic load - Wikipedia
wikipedia.org

https://en.wikipedia.org/wiki/Genetic_load

WebDeterministic accumulation of mutation load occurs in asexuals when the deleterious mutation rate exceeds one per replication. Sexually reproducing species are expected to have lower genetic loads. This is one hypothesis …

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Estimating the mutation load in human genomes - Nature
nature.com

https://www.nature.com/articles/nrg3931

WebMay 12, 2015 · This Review examines the frequency and patterns of deleterious alleles in the human genome and considers recent studies with conflicting findings on whether the mutation load, or burden of ...

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Genetic load: genomic estimates and applications in non-model …
nature.com

https://www.nature.com/articles/s41576-022-00448-x

WebFeb 8, 2022 · 58 Citations. 119 Altmetric. Metrics. Abstract. Genetic variation, which is generated by mutation, recombination and gene flow, can reduce the mean fitness of a population, both now and in the...

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Estimating Mutation Load in Human Genomes - PMC - National …
nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4959039/

WebMutational load is the component of genetic load attributable to the reduction in fitness caused by new and recent deleterious mutations. Other components of genetic load include: the segregation load, the inbreeding load, and the transitory load.

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Direct Evidence of an Increasing Mutational Load in Humans
oup.com

https://academic.oup.com/mbe/article/36/12/2823/5551346

WebAug 13, 2019 · Direct Evidence of an Increasing Mutational Load in Humans. Stéphane Aris-Brosou. Author Notes. Molecular Biology and Evolution, Volume 36, Issue 12, December 2019, Pages 2823–2829, https://doi.org/10.1093/molbev/msz192. Published: 13 August 2019. PDF. Split View. Cite. Permissions. Share. Abstract.

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Mutation load is the spectre of species conservation - Nature
nature.com

https://www.nature.com/articles/s41559-020-1204-8

WebMay 4, 2020 · The mutation load consists of recessive deleterious alleles that are segregating in the population (that is, the ‘segregation load’), and mutations that have...

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Mutational Load - an overview | ScienceDirect Topics
sciencedirect.com

https://www.sciencedirect.com/topics/medicine-and-dentistry/mutational-load

WebCertain types of mtDNA mutation affect specific organs. Moreover, the mutation load of mtDNA in each cell, which is called “heteroplasmy,” contributes to the severity of the disease phenotype. Each organ or cell type has its own threshold to manifest a dysfunction.

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Mutational Load - an overview | ScienceDirect Topics
sciencedirect.com

https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/mutational-load

WebThe potential deleteriousness of mutational load (excessive number of mutations in the same genome) is symbolized in Figure 9.1 by the genomes drawn as discontinuous lines that contain five mutations, here assumed to be a sufficiently large number to decrease fitness and, therefore, the frequency of their potential descendants in subsequent repl...

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Genetic Load | SpringerLink
springer.com

https://link.springer.com/referenceworkentry/10.1007/978-3-319-19650-3_2337

WebJan 1, 2021 · Definition. Genetic load describes the fitness burden resulting (principally) from deleterious mutations that accumulate within an organism’s genome and is estimated relative to a hypothetical mutation-free or fitness-optimized genome.

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Mutational Load and the Functional Fraction of the Human Genome
nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151545/

WebIn this article, we examine whether and how an analysis based on mutational load might set a limit on the functional fraction. In order to do so, we characterize the distribution of fitness of a large, finite, diploid population at mutation-selection equilibrium.

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