It’s required for a metabolic process that repairs DNA, switches genes on and off, and numerous other important functions ( 1 ). MTHFR is also essential to convert folate and folic acid – each a form of Vitamin B9 – into the biologically active form called L-methylfolate (or 5-MTHF).What is the MTHFR C677T variant of folate?
Folate includes naturally occurring folates in foods, such as leafy green vegetables, citrus fruits, and beans, and several types of folate in dietary supplements, such as folic acid and 5-methyltetrahydrofolate (5-MTHF). The MTHFR C677T variant affects how your body processes folate.Can I take 5-MTHF If I have MTHFR C677T?
You may have heard or read that if you have an MTHFR C677T variant, you should take other types of folate (such as 5-MTHF), but this is not true. Folic acid is the only type of folate shown to help prevent neural tube defects (severe birth defects of the brain or spine). 1-4What is the MTHFR A1298C variant?
Another common gene variant is the MTHFR A1298C variant. This gene variant occurs at the 1298 position in the MTHFR gene.