letrozole mechanism of action | Letrozole: Uses, Interactions, Mechani

Keyword	CPC	PCC	Volume	Score	Length of keyword
letrozole mechanism of action	1.18	0.2	1648	20	29
letrozole	0.99	0.3	3805	49	9
mechanism	0.05	0.9	8493	98	9
of	1.11	0.6	1279	52	2
action	1.93	0.4	6971	33	6

Keyword	CPC	PCC	Volume	Score
letrozole mechanism of action	1.42	0.8	4016	41
letrozole mechanism of action fertility	0.53	0.9	9704	10
letrozole mechanism of action in pcos	0.24	0.9	9684	68
letrozole mechanism of action breast cancer	0.9	0.4	9668	90
letrozole mode of action	1.07	0.6	8014	54
letrozole mech of action	1.83	0.5	6372	66
letrozole how does it work	1.78	0.6	2747	27
letrozole duration of action	0.5	0.6	7457	12
what does letrozole do	1.36	0.8	8140	49
what does letrozole do to the body	0.36	0.3	2686	15
letrozol mecanismo de accion	1.69	0.4	5442	48
how to manage side effects of letrozole	1.68	0.8	4888	45
letrozole and liver function	1.29	0.6	8898	84
letrozole effect on immune system	1.36	0.9	678	49
letrozole route of administration	1.07	0.5	8400	23
letrozole used to treat	0.46	0.1	6916	88
how to treat letrozole side effects	1.54	0.8	4803	24

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Letrozole: Uses, Interactions, Mechanism of Action | DrugBank …
drugbank.com

https://go.drugbank.com/drugs/DB01006

WebMechanism of action. Letrozole is a non-steroidal type II aromatase inhibitor. 5 It blocks the active site, and therefore the electron transfer chain of CYP19A1. 5 This competitive inhibition prevents the conversion of androgens to estrogen. 5 This action leads to a reduction in uterine weight and elevated leuteinizing hormone. 9 In ...

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Letrozole - Wikipedia
wikipedia.org

https://en.wikipedia.org/wiki/Letrozole

WebLetrozole is an orally active, nonsteroidal, selective aromatase inhibitor and hence an antiestrogen. It prevents aromatase from producing estrogens by competitive, reversible binding to the heme of its cytochrome P450 unit. The action is specific, and letrozole does not reduce production of corticosteroids. [citation needed

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The discovery and mechanism of action of letrozole - PMC
nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001216/

WebOct 3, 2007 · The discovery of letrozole (Femara ®) achieved the goal of discovering a highly potent and totally selective AI. Letrozole has greater potency than other AIs, including anastrozole, exemestane, formestane, and aminoglutethimide.

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Letrozole: A Well-Tolerated and Effective Treatment for Breast Cancer
sagepub.com

https://journals.sagepub.com/doi/full/10.2217/17455057.2.5.673

WebMechanism of action. Endogenous estrogen induces tumor growth in the majority of women with hormone receptor-positive breast cancer by stimulating the estrogen receptor (ER), and treatments have focused on reducing the levels of estrogen in women with endocrine-responsive breast cancer.

DA: 50 PA: 35 MOZ Rank: 64

Letrozole: Dosage, Mechanism/Onset of Action, Half-Life
medicine.com

https://www.medicine.com/drug/letrozole/hcp

WebFeb 17, 2020 · Mechanism of Action. Letrozole is a nonsteroidal competitive inhibitor of the aromatase enzyme system which binds to the heme group of aromatase, a cytochrome P450 enzyme which catalyzes conversion of androgens to estrogens (specifically, androstenedione to estrone and testosterone to estradiol).

DA: 60 PA: 20 MOZ Rank: 46

Aromatase Inhibitors - StatPearls - NCBI Bookshelf
nih.gov

https://www.ncbi.nlm.nih.gov/books/NBK557856/

WebJul 4, 2023 · Objectives: Describe the mechanism of action of aromatase inhibitors. Summarize the potential adverse reactions and contraindications of aromatase inhibitor use. Review the indicated uses for aromatase inhibitors in current medical practice.

DA: 46 PA: 19 MOZ Rank: 41

Letrozole: Pharmacology, toxicity and potential therapeutic effects
sciencedirect.com

https://www.sciencedirect.com/science/article/pii/S0024320522007743

WebDec 1, 2022 · Abstract. The highly active estrogen metabolism and receptor protein expression are to blame for the elevated breast cancer (BC) rate in post-menopausal women. Letrozole is a powerful endocrine medication that targets and inhibits the aromatase, often known as an aromatase inhibitor (AI).

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Letrozole: Advancing Hormone Therapy in Breast Cancer
sagepub.com

https://journals.sagepub.com/doi/10.2217/WHE.12.49

WebNov 1, 2012 · This review will examine the mechanism of action of letrozole, as well as its pharmacodynamics, efficacy and safety. Pharmacology. Aromatase is an enzyme of the CYP450 family and catalyzes the conversion of estrone from androstenedione and estradiol from testosterone [ 3 ].

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Letrozole - NCI - National Cancer Institute
cancer.gov

https://www.cancer.gov/about-cancer/treatment/drugs/letrozole

WebLetrozole is approved to be used alone or with other drugs to treat: Breast cancer in postmenopausal women who have any of the following types of breast cancer--. Early-stage, hormone receptor–positive (HR+) breast cancer that has been treated.

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The discovery and mechanism of action of letrozole - PMC
nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969790/

WebDec 13, 2007 · This corrects the article "The discovery and mechanism of action of letrozole" in Breast Cancer Res Treat, volume 105 on page 7. Erratum to: Breast Cancer Res Treat (2007) 105(Suppl 1) DOI 10.1007/s10549-007-9696-3

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