Keyword Analysis & Research: hsp90


Keyword Analysis

Keyword CPC PCC Volume Score Length of keyword
hsp900.870.76805655

Keyword Research: People who searched hsp90 also searched

Keyword CPC PCC Volume Score
hsp900.370.3739731
hsp90aa11.460.8277889
hsp90 inhibitor0.510.9681916
hsp90ab11.360.7715015
hsp90b10.82117439
hsp90 antibody1.920.2867397
hsp90 gene1.680.7905633
hsp90 function1.020.4455977
hsp90 protein1.40.241142
hsp90 structure0.70.1904491
hsp90 uniprot1.050.6457948
hsp90 beta0.250.6659966
hsp90aa1 gene0.130.6793961
hsp90 alpha1.750.116562
hsp90 beta antibody1.780.3375593

Search Results related to hsp90 on Search Engine

  • Hsp90 - Wikipedia

    wikipedia.org

    https://en.m.wikipedia.org/wiki/Hsp90

    WebHsp90 (heat shock protein 90) is a chaperone protein that assists other proteins to fold properly, stabilizes proteins against heat stress, and aids in protein degradation. It also stabilizes a number of proteins required for tumor growth, which is why Hsp90 inhibitors are investigated as anti-cancer drugs.

    DA: 73 PA: 79 MOZ Rank: 31

  • The HSP90 chaperone machinery | Nature Reviews Molecular …

    nature.com

    https://www.nature.com/articles/nrm.2017.20

    WebApr 21, 2017 · Key Points. Heat shock protein 90 (HSP90) is a molecular chaperone that is conserved from bacteria to humans and facilitates the maturation of substrates (or clients) that are involved in...

    DA: 32 PA: 48 MOZ Rank: 42

  • Hsp90: structure and function - PubMed

    nih.gov

    https://pubmed.ncbi.nlm.nih.gov/22955504/

    WebAbstract. Hsp90 is a highly abundant and ubiquitous molecular chaperone which plays an essential role in many cellular processes including cell cycle control, cell survival, hormone and other signalling pathways. It is important for the cell's response to stress and is a key player in maintaining cellular homeostasis.

    DA: 87 PA: 67 MOZ Rank: 3

  • The HSP90 Family: Structure, Regulation, Function, and …

    nih.gov

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164434/

    WebAug 29, 2018 · HSP90 proteins take part in essential cellular processes and regulatory pathways like apoptosis, cell cycle control, cell viability, protein folding and degradation, and signalling events. In addition, they induce the adaptive immunity by activation of antigen presenting cells and dendritic cells.

    DA: 20 PA: 63 MOZ Rank: 36

  • Structural and functional complexity of HSP90 in cellular ... - Nature

    nature.com

    https://www.nature.com/articles/s41580-023-00640-9

    WebJul 31, 2023 · Abstract. Heat shock protein 90 (HSP90) is a chaperone with vital roles in regulating proteostasis, long recognized for its function in protein folding and maturation. A view is...

    DA: 25 PA: 28 MOZ Rank: 10

  • HSP90 at the hub of protein homeostasis: emerging mechanistic …

    nature.com

    https://www.nature.com/articles/nrm2918

    WebJun 9, 2010 · HSP90 is one of the most abundant proteins in the cytoplasm, where it constitutes 1–2% of total protein levels 20. Some HSP90 translocates to the nucleus in response to stress and other stimuli...

    DA: 35 PA: 33 MOZ Rank: 9

  • The HSP90 Family: Structure, Regulation, Function, and ... - PubMed

    nih.gov

    https://pubmed.ncbi.nlm.nih.gov/30158430/

    WebAug 29, 2018 · Therefore, targeting HSP90 is an attractive strategy for the treatment of neoplasms and other diseases. This manuscript will review the general structure, regulation and function of HSP90 family and their potential role in pathophysiology.

    DA: 64 PA: 63 MOZ Rank: 40

  • Hsp90 in Human Diseases: Molecular Mechanisms to …

    nih.gov

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946885/

    WebMar 12, 2022 · A great body of the literature indicates a critical inhibitory contribution of Hsp90 to apoptosis which is key to normal cell growth or adverse tumor progression. Hsp90 is known to inhibit apoptosis by directly binding to Apaf-1, blocking cytochrome c-mediated oligomerization of Apaf-1 and the activation of pro-caspase 9 .

    DA: 57 PA: 9 MOZ Rank: 41

  • Old and New Approaches to Target the Hsp90 Chaperone - PMC

    nih.gov

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7502213/

    WebThe 90-kDa heat shock protein (Hsp90) is a molecular chaperone that ensures cellular proteostasis by maintaining the folding, stabilization, activation, and degradation of over 400 client proteins. Hsp90 is not only critical for routine protein maintenance in healthy cells, but also during states of cellular stress, such as cancer and ...

    DA: 83 PA: 61 MOZ Rank: 11

  • Targeted delivery of HSP90 inhibitors for efficient therapy of CD44

    biomedcentral.com

    https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-024-02460-1

    Web2 days ago · Heat shock protein 90 (HSP90), known as a vital molecular chaperone, is discovered to regulate numerous cellular processes, including functional maturation, folding and activation of more than 200 client proteins [1,2,3].HSP90 is overexpressed in various cancers, and is considered to promote the maturation of many oncoproteins and facilitate cancer cell growth [4, 5].

    DA: 62 PA: 40 MOZ Rank: 63