Keyword Analysis & Research: cdaa hfd


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What does cdahfd stand for?

Male mice were fed a choline-deficient, L-amino acid-defined, high-fat diet (CDAHFD) consisting of 60 kcal% fat and 0.1% methionine by weight. After 1-14 weeks of being fed CDAHFD, the mice were killed. C57BL/6J mice maintained or gained weight when fed CDAHFD, while A/J mice showed a steady decline in body weight (of up to 20% of initial weight).

What is the CDAA diet?

The CDAA diet is a diet of 30 kcal% fat content containing Primex and corn oil as fat and containing 0.17% methionine to compensate for choline deficiency (Nakae et al. 1990, 1992 ). This CDAA diet was originally developed as a model to strongly and rapidly cause hepatocellular carcinoma in Fischer 344 or Wistar rats.

Is cdahfd a mouse model of Nash disease?

Therefore, this improved CDAHFD model may be a mouse model of rapidly progressive liver fibrosis and be potentially useful for better understanding human NASH disease and in the development of efficient therapies for this condition. Keywords: fibrosis; high-fat diet; methionine-restricted diet; mouse model; non-alcoholic steatohepatitis.

What is the difference between MCD and CDAA feeding in mice?

In C57Bl/6J mice, MCD feeding resulted in moderate fibrosis at week 8 (up to twofold increase in total hepatic collagen content) and progressive weight loss irrespective of dietary fat. In contrast, CDAA-fed mice did not lose weight and developed progressive fibrosis starting from week 4.


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