brca1 | BRCA1 - Wikipedia

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BRCA1 - Wikipedia
wikipedia.org

https://en.wikipedia.org/wiki/BRCA1

WEBBRCA1 is a human tumor suppressor gene [7] [8] (also known as a caretaker gene) and is responsible for repairing DNA. [9] BRCA1 and BRCA2 are unrelated proteins, [10] but both are normally expressed in the cells of breast and other tissue, where they help repair damaged DNA, or destroy cells if DNA cannot be repaired.

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BRCA Gene Mutations: Cancer Risk and Genetic Testing
cancer.gov

https://www.cancer.gov/about-cancer/causes-prevention/genetics/brca-fact-sheet

WEBBRCA1 and BRCA2 are sometimes called tumor suppressor genes because when they have certain changes, called harmful (or pathogenic) variants (or mutations), cancer can develop. People who inherit harmful variants in one of these genes have increased risks of several cancers—most notably breast and ovarian cancer, but also several additional ...

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The BRCA1 and BRCA2 Genes | CDC
cdc.gov

https://www.cdc.gov/genomics/disease/breast_ovarian_cancer/genes_hboc.htm

WEBThe genes most commonly affected in hereditary breast and ovarian cancer are the breast cancer 1 (BRCA1) and breast cancer 2 (BRCA2) genes. About 3% of breast cancers (about 7,500 women per year) and 10% of ovarian cancers (about 2,000 women per year) result from inherited mutations in the BRCA1 and BRCA2 genes.

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BRCA gene test for breast and ovarian cancer risk - Mayo Clinic
mayoclinic.org

https://www.mayoclinic.org/tests-procedures/brca-gene-test/about/pac-20384815

WEBOct 21, 2023 · BRCA1 and BRCA2 are the most well-known genes. Testing often looks for those genes and many other genes that increase the risk of breast and ovarian cancers. Changes in these genes significantly increase the risk of many cancers, including: Breast cancer. Male breast cancer. Ovarian cancer. Prostate cancer. Pancreatic cancer.

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Inherited Cancer Risk: BRCA Mutation | Johns Hopkins Medicine
hopkinsmedicine.org

https://www.hopkinsmedicine.org/health/conditions-and-diseases/breast-cancer/inherited-cancer-risk-brca-mutation

WEBInheriting damaged copies of the BRCA1 or BRCA2 genes can increase the risk for breast cancer and ovarian cancer in women and the risk for breast and prostate cancer in men, as well as other cancers. Here is what you need to know about genetic factors in breast cancer, who may be at risk and how people with BRCA mutations can work with their ...

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BRCA1 gene: MedlinePlus Genetics
medlineplus.gov

https://medlineplus.gov/genetics/gene/brca1/

WEBThe BRCA1 gene provides instructions for making a protein that acts as a tumor suppressor. Tumor suppressor proteins help prevent cells from growing and dividing too rapidly or in an uncontrolled way. The BRCA1 protein is involved in repairing damaged DNA.

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BRCA1 and BRCA2 (PDQ®) - NCI - National Cancer Institute
cancer.gov

https://www.cancer.gov/about-cancer/causes-prevention/genetics/brca-genes-hp-pdq

WEBEvidence-based, expert-reviewed summary about the BRCA1 and BRCA2 genes and hereditary breast and ovarian cancer. This summary also contains information about the cancer risks associated with BRCA1/BRCA2, screening, …

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About Mutations in the BRCA1 Gene - Memorial Sloan Kettering …
mskcc.org

https://www.mskcc.org/cancer-care/patient-education/about-mutations-brca1-gene

WEBJul 16, 2023 · Patient & Community Education. About Mutations in the BRCA1 Gene. Time to Read: About 3 minutes. This information explains how having a mutation in the BRCA1 gene may affect you and your family. In this resource, the word “family” means people related to you by blood. They’re not related to you through marriage or adoption.

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BRCA1 and Breast Cancer: Molecular Mechanisms and Therapeutic
nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921524/

WEBMar 1, 2022 · Breast cancer susceptibility gene 1 ( BRCA1) is a tumor suppressor gene, which is mainly involved in the repair of DNA damage, cell cycle regulation, maintenance of genome stability, and other important physiological processes.

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BRCA - Health Encyclopedia - University of Rochester Medical …
rochester.edu

https://www.urmc.rochester.edu/encyclopedia/content.aspx?ContentTypeID=167&ContentID=brca

WEBSearch Encyclopedia. BRCA. Does this test have other names? BRCA gene 1, BRCA gene 2, breast cancer susceptibility gene 1, breast cancer susceptibility gene 2. What is this test? This blood test checks for mutations in the BRCA1 and BRCA2 genes.

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