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What does nonsense mutation mean?

Nonsense Mutation Definition 1. A point mutation occurring within the protein-coding region of a gene, and which codes for a stop that can truncate the protein. (NCI Thesaurus) Definition 2. A mutation that alters the genetic code in a way that causes the premature termination of a protein.

What is a nonsense mutaion?

Nonsense mutation: A mutation (a change) in a base in the DNA that prematurely stops the translation (reading) of messenger RNA (mRNA) resulting in a polypeptide chain that ends prematurely and a protein product that is truncated (abbreviated) and incomplete and usually nonfunctional.


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